Royal Devon University Healthcare NHS Foundation Trust was caring for 61 patients with coronavirus in hospital as of Sunday, figures show.
NHS England data shows the number of people being treated in hospital with Covid-19 by 8am on September 24 was up from 38 on the same day the previous week.
Across England there were 3,087 people in hospital with Covid as of September 24.
Nationally, the number of hospital patients with Covid-19 has increased by 22% in the last four weeks.
The figures also show that 90 new patients with Covid were admitted to hospital in Royal Devon University Healthcare NHS Foundation Trust in the week to September 22.